The IMRB Grant Office – GO-IMRB, had the pleasure of supporting four submissions to the ANR 2024 AAPG: The harvest was excellent as all four were funded!

Find out more about the winners and their comments on the help provided by the GO IMRB in setting up their project.

 

HidSup ANR CE14-PRC: Hair follicle stem cells: new players in the pathophysiology of hidradenitis suppurativa (HS)
Coordinator: Sophie HUE, LEVY team
Consortium: 2 IMRB partners.

The aim of this project is to dissect the role of keratinisation in HS and its involvement in the inflammatory process, and also to identify new targets (proteins, cell types) in order to develop new therapeutic options targeting the keratinisation process.

According to its coordinator, the GO-IMRB’s little plus during the setting up of HidSup: ‘The GO-IMRB helped me to structure and clarify certain scientific ideas. Regular discussions with the GO-IMRB enrich the project and help it to mature. By taking on administrative and financial tasks, the GO-IMRB has also enabled me to concentrate more on the scientific part of the project’.

 

CypI-DILI ANR CE17-PRC : Preclinical evaluation of a new cyclophilin inhibitor in drug-induced liver damage
Coordinator: Fatima TEIXEIRA-CLERC, PAWLOTSKY team
Consortium: 1 IMRB partner plus 2 partners from Montpellier & Marseille.

This research programme aims to strengthen the evidence base for the therapeutic potential of a novel CypD inhibitor in in vitro and in vivo models of paracetamol-induced liver injury and to elucidate the molecular mechanisms of CypD-mediated and CypD-independent mPTP opening.

According to its coordinator, the GO-IMRB’s little extra during the preparation of CypI-DILI: ‘The GO-IMRB gave me valuable advice during phase 2 to make the introduction to my proposal more fluid and to highlight the originality of my project. It also helped me to strengthen my right of reply’.

 

PRIMe ANR CE34 -PRC: Impact of air pollution on the resolution of inflammation in cystic fibrosis
Coordinator: Valérie URBACH, LANONE team
Consortium: 1 IMRB partner plus 2 partners (LISA & CHIC).

The PRIMe project aims to identify the mechanisms by which air pollution impacts the phenotypic variability of airway disease observed in cystic fibrosis (CF) patients by affecting the resolution phase of inflammation.

According to its coordinator, the GO-IMRB’s little extra during the setting up of PRIMe: ‘I am particularly grateful to the GO-IMRB for helping me to use my right of reply in the second phase, in a confident and incisive way’.

 

SCOOP ANR CE17-PRC: Role of satellite cells in COPD-associated sarcopenia
Coordinator: Laurent BOYER, DERUMEAUX team
Consortium: 2 IMRB partners plus 1 partner from Bordeaux.

The aim of this research programme is to improve our understanding of the biology of muscle stem cells, which offer hope for the development of therapies to improve muscle regeneration and combat the sarcopenia studied here in the context of COPD.

 

Don’t hesitate to contact the GO-IMRB for your next submissions!