Oliver BISCHOF and José AMERICO FREITAS, DERUMEAUX team, co-authors of a publication in NATURE METABOLISM on the role of a homeostatic switch which causes the accumulation of glycerol-3-phosphate and phosphoethanolamine, and triggers senescence by reorganising lipid metabolism.

José AMERICO FREITAS, and Oliver BISCHOF, co-corresponding author, DERUMEAUX team, together with scientists from Inserm, Université Paris Cité, CNRS and Institut Necker Enfants Malades, have published a promising study on age-related diseases in the journal NATURE METABOLISM on 19 February 2024.

Cellular senescence affects many physiological and pathological processes and is characterised by sustained cell cycle arrest, an inflammatory secretory phenotype and metabolic reprogramming. Here, using dynamic transcriptome and metabolome profiling in human fibroblasts exhibiting different subtypes of senescence, the study shows that a homeostatic switch that results in the accumulation of glycerol-3-phosphate (G3P) and phosphoethanolamine (pEtN) links lipid metabolism to the senescence gene expression programme.

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