Treg-targeted IL-2/anti-IL-2 complex controls graft-versus-host disease and supports anti-tumor effect in allogeneic hematopoietic stem cell transplantation

The work of Allan Thiolat and Caroline Pilon, members of José Cohen’s Immunoregulation and Biotherapy (I-BIOT) team, recently published in the September 14, 2023 issue of Haematologica (https://haematologica.org/article/download/haematol.2022.282653/76051), has just been reprinted in the September 15, 2023 issue of Stem cells Science News in the Immune Regulation News section (https://www.stemcellsciencenews.com/newsletter/213994/).

This is the first study to compare side-by-side the respective effects of two complexes [IL-2/Ac anti-IL-2] designed to activate either regulatory or effector T cells. This work demonstrates the advantage of the pro-regulatory T complex both in terms of graft-versus-host disease control and the anti-leukemic effect produced.