Discovery of a new molecule called TMEM9B-AS1, which could explain why people with type 2 diabetes often suffer from muscle weakness and loss of muscle mass

A study published in Sciences Advances, and conducted by researchers from Karolinska Institutet, Innlandet University in Lillehammer, Norway, and IMRB’s DERUMEAUX team, has uncovered a previously unknown molecule that could explain why people with type 2 diabetes often suffer from muscle weakness and loss.

This molecule, TMEM9B-AS1, is a long non-coding RNA that plays an important role in the regulation of cellular functions.
Members of the DERUMEAUX team, Ilke SEN, CPJ Inserm, and Iurii ORLOV, postdoctoral fellow, are respectively corresponding author and co-author of this article.

Access to the article published in Sciences Advances, vol 11 issue 28, July 9, 2025.

The team is also working on the proofs of another article which was recently accepted by the journal Nature Communications and which will also be published shortly.

Finally, click on this link to read the team’s article published in Circulation on May 23, 2025: Aging at the Crossroads of Organ Interactions: Implications for the Heart.