Interventional neuropsychology

The NeuroPsychologie Interventionnelle (NPI) team, INSERM U955, is a mixed research unit (INSERM, UPEC, ENS). The team is led by Prof. Anne-Catherine Bachoud.

The NPI team is present on two sites :
– the Mondor Institute of Biomedical Research (Faculty of Medicine of the UPEC in Créteil) dedicated to clinical research
– the Department of Cognitive Studies of the Ecole Normale Supérieure in Paris, focused on research in neuroscience and cognitive sciences.

Research axes :

The NPI’s approach is threefold:

  • Basic research in adult cognition, particularly language…
  • Development of digitized diagnostic and monitoring tools for small cohorts of people
  • Application to innovative therapies and predictive models of decline and recovery

The originality of the team lies in the convergence between fundamental research in human cognition and communication, and translational research focused on the evaluation of innovative therapies such as cell transplantation and gene therapy in neurodegenerative diseases (Huntington’s and Parkinson’s disease) and in vascular pathologies.


The clinical research projects we have developed are based on the original concept of interventional neuropsychology, which means that we study cognitive functions not only by their decline but also by their restoration following therapeutic intervention.


In order to improve the treatment and care of patients suffering from degenerative or vascular diseases, we capitalize on our expertise in cognition, particularly language and social cognition, to develop new digital tools for diagnosis, prognosis and patient follow-up. The long-term objective is to develop a dematerialized cognitive monitoring system that allows patients to be monitored even at home.


Key words :

Language; Psycholinguistics; Linguistics; Cognition; Neurodegenerative disease; Huntington’s; Parkinson’s; Intracerebral transplants; Striatum; fMRI; EEG; Social cognition; Stroke; Psycholinguistics


External collaborations :

The NPI laboratory is a member of the NeurATRIS health and biology research infrastructure designed to develop innovative tools for the development of future treatments. It also participates in the FHU SENEC (2020) in order to adapt new tools to cognitive impairment in aging. The NPI’s activity is supported by the National Reference Centre for Huntington’s disease, the Parkinson’s expert centre and a vascular recourse unit providing access to patient cohorts (AP-HP; Henri Mondor Hospital; Créteil).


Selected publications

Bachoud-Lévi AC, Ferreira J, Massart R, Youssov K, Rosser A, Busse M, Craufurd D, Reilmann R, De Michele G, Rae D, Squitieri F, Seppi K, Perrine C, Scherer-Gagou C, Audrey O, Verny C, Burgunder JM. International Guidelines for the Treatment of Huntington's Disease.

Front Neurol. 2019 Jul 3;10:710. doi: 10.3389/fneur.2019.00710. eCollection 2019.

Jacquemot C, Lalanne C, Sliwinski A, Piccinini P, Dupoux E, Bachoud-Lévi AC. Improving language evaluation in neurological disorders: The French Core Assessment of Language Processing (CALAP).

Psychol Assess. 2019 May;31(5):622-630.

Giavazzi M, Daland R, Palminteri S, Peperkamp S, Brugieres P, Jacquemot C, Schramm C, Cleret de Langavant L, Bachoud-Levi AC. The role of the striatum in linguistic selection: Evidence from Huntington's disease and computational modeling.

Cortex, 2018 Dec;109:189-204

Cleret de Langavant L, Bayen E, Yaffe K. Unsupervised machine learning to identify high likelihood of dementia in population-based surveys.

J Med Internet Res, 2018 Jul 9;20(7):e10493. doi: 10.2196/10493.

Schramm C, Vial C, Bachoud-Lévi AC, Katsahian S. Clustering of longitudinal data by using an extended baseline: A new method for treatment efficacy clustering in longitudinal data.

Stat Methods Med Res. (2018) janv 27(1):97-113.

Mestre, TA ; Bachoud-Lévi, AC ; Marinus, J ; Stout, JC ; Paulsen, JS ; Como, P & al. Rating scales for cognition in Huntington's disease: Critique and recommendations.

Mov. Disorders. 2018. 33(187-195). PMID: 29278291

Gaura V, Lavisse S, Payoux P, Goldman S, Verny C, Krystkowiak P, Damier P, Supiot F, Bachoud-Levi AC, Remy P. Association Between Motor Symptoms and Brain Metabolism in Early Huntington Disease.

JAMA Neurol. 2017 Sep 1;74(9):1088-1096 . PMID: 28672395

Trinkler I, Devignevielle S, Achaibou A, Ligneul RV, Brugières P, Cleret de Langavant L, De Gelder B, Scahill R, Schwartz S, Bachoud-Lévi AC. Embodied emotion impairment in Huntington's Disease.

Cortex. 2017 Jul; 92:44-56. PMID:28399433

de Diego-Balaguer* R, Schramm* C, Rebeix I, Dupoux E, Durr A, Brice A, Charles P, Cleret de Langavant L, Youssov K, Verny C, Damotte V, Azulay JP, Goizet C, Simonin C, Tranchant C, Maison P, Rialland A, Schmitz D, Jacquemot C, Fontaine B, Bachoud-Lévi AC; French Speaking Huntington Group. COMT Val158Met Polymorphism Modulates Huntington's Disease Progression.

PLoS One. 2016 Sep 22;11(9):e0161106. PMID: 2765769

Salem L, Saleh N, Désaméricq G, Youssov K, Dolbeau G, Cleret L, Bourhis ML, Azulay JP, Krystkowiak P, Verny C, Morin F, Moutereau S; French Huntington Study Group., Bachoud-Lévi AC, Maison P. Insulin-Like Growth Factor-1 but Not Insulin Predicts Cognitive Decline in Huntington's Disease.

PLoS One. 2016 Sep 14;11(9):e0162890. PMID: 27627435

Visser E, Keuken MC, Douaud G, Gaura V, Bachoud-Lévi AC, Remy P, Forstmann BU, Jenkinson M. Automatic segmentation of the striatum and globus pallidus using MIST: Multimodal Image Segmentation Tool.

Neuroimage. 2016 Jan 15;125:479-497

Significant publications (2009-2015)